Chronic Granulomatous Disease

A defect of leukocyte function in which phagocytic cells ingest but fail to digest bacteria, resulting in recurring bacterial infections with granuloma formation. When chronic granulomatous disease is caused by mutations in the CYBB gene, the condition is inherited in an X-linked recessive pattern. When chronic granulomatous disease is caused by CYBA, NCF1, NCF2, or NCF4 gene mutations, the condition is inherited in an autosomal recessive pattern.

Also Known As:

Granulomatous Disease, Chronic; Autosomal Recessive Chronic Granulomatous Disease; Chronic Granulomatous Disease, Atypical; Chronic Granulomatous Disease, X-Linked; Cytochrome B-Negative Granulomatous Disease, Chronic, X-Linked; Cytochrome B-Positive Granulomatous Disease, Chronic, X-Linked; Granulomatous Disease, Chronic, X-Linked; Granulomatous Disease, Chronic, X-Linked, Variant; X-Linked Chronic Granulomatous Disease; Chronic Granulomatous Disease, X Linked; Chronic Granulomatous Diseases; Granulomatous Diseases, Chronic; X Linked Chronic Granulomatous Disease

Hemic and Lymphatic Diseases: 7
- Hematologic Diseases: 3445
  - Leukocyte Disorders: 8
    - Phagocyte Bactericidal Dysfunction
      - Chronic Granulomatous Disease: 1850
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 960
- Inborn Genetic Diseases: 12342
  - X-Linked Genetic Diseases: 42
    - Chronic Granulomatous Disease: 1850
Immune System Diseases: 4430
- Immunologic Deficiency Syndromes: 91
  - Phagocyte Bactericidal Dysfunction
    - Chronic Granulomatous Disease: 1850
Signs and Symptoms Pathological Conditions
- Pathologic Processes: 10385
  - Disease Attributes: 18
    - Chronic Disease: 26704
      - Chronic Granulomatous Disease: 1850

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Drug/Important Bio-Agent (IBA)